Investigating how statins and colchicine affect coronary plaque in high-risk individuals
Coronary plaque changes with statin and colchicine among people with high polygenic risk- a mechanistic pilot study
This study is looking at people who have a high genetic risk for heart disease but don’t have the usual warning signs, to see if the medications statins and colchicine can help reduce heart plaque and lower their risk of heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10874668 on NIH RePORTER |
What this research studies
This research focuses on individuals identified as having a high genetic risk for coronary artery disease (CAD) who may not show typical clinical risk factors. It aims to explore how the medications statins and colchicine can influence coronary plaque formation and regression in these patients. By utilizing advanced genomic medicine techniques and non-invasive imaging, the study will assess the effectiveness of these treatments in reducing cardiovascular risks. Participants will be drawn from a hospital biobank, allowing for a comprehensive analysis of their coronary health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a high polygenic risk score for coronary artery disease who do not have known cardiovascular disease.
Not a fit: Patients who do not have a high genetic risk for coronary artery disease or those with existing cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for individuals at high genetic risk for coronary artery disease, potentially reducing their risk of heart attacks and other cardiovascular events.
How similar studies have performed: Previous research has shown promise in using genetic risk scores and pharmacological interventions to manage cardiovascular disease, indicating that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Fahed, Akl C — Massachusetts General Hospital
- Study coordinator: Fahed, Akl C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.