Investigating how statins affect knee osteoarthritis progression
Effect of statin intake on Non-traumatic Generalized Knee Osteoarthritis
This study is looking at how statin medications might help protect your knees from getting worse if you have mild bone issues and osteoarthritis, especially if it runs in your family.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10916304 on NIH RePORTER |
What this research studies
This research aims to explore the protective effects of statin medications on the progression of non-traumatic generalized knee osteoarthritis (GOA) in patients who show minimal bone marrow lesions. By examining both human subjects and dyslipidemia-associated mouse models, the study will investigate the mechanisms through which statins may benefit the subchondral bone. The research will focus on patients with familial GOA and polyarticular involvement, assessing how statins might mitigate the effects of dyslipidemia and atherosclerosis on knee health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-traumatic generalized knee osteoarthritis who have minimal subchondral bone marrow lesions.
Not a fit: Patients with traumatic knee osteoarthritis or those without dyslipidemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from knee osteoarthritis, potentially slowing disease progression.
How similar studies have performed: Previous studies have shown promising results regarding the protective effects of statins in animal models, but clinical evidence in humans has been inconsistent, making this research both relevant and necessary.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Demehri, Shadpour — Johns Hopkins University
- Study coordinator: Demehri, Shadpour
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.