Investigating how specific RNAs influence blood cell formation
Understanding the role of cell-cycle specific RNAs in hematopoiesis
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11113810
This study is looking at how certain special RNAs can help fix problems with blood cell production caused by changes in DNA, which often happen in blood cancers, and aims to find safer treatments that could help patients with these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11113810 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of specialized RNAs in regulating the production of blood cells, particularly in the context of abnormal DNA methylation, which is a common issue in blood cancers. The researchers aim to develop a targeted approach to correct these methylation errors without the high toxicity associated with current treatments. By studying how these RNAs interact with key enzymes involved in DNA methylation, the project seeks to uncover new strategies for treating hematological malignancies. Patients may benefit from more effective and safer therapies for blood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with blood cancers or disorders related to abnormal blood cell formation.
Not a fit: Patients with non-hematological conditions or those not affected by blood cell formation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for blood cancers and related disorders.
How similar studies have performed: Previous research has shown promise in targeting specific RNA interactions for therapeutic purposes, indicating potential success for this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DI RUSCIO, ANNALISA — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: DI RUSCIO, ANNALISA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease, blood cancer