Investigating how specific receptors affect non-alcoholic fatty liver disease
PPARa and related nuclear receptors in non-alcoholic fatty liver disease
This study is looking at how certain proteins in your body affect fat buildup in the liver, which can lead to non-alcoholic fatty liver disease (NAFLD), with the hope of finding new ways to treat this condition and help people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11084443 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the PPARα nuclear receptor and its interactions with other receptors in the development of non-alcoholic fatty liver disease (NAFLD). By examining how these receptors influence gene regulation related to lipid metabolism, the study aims to identify potential therapeutic targets for treating NAFLD. The research involves both laboratory experiments and analysis of genetic data to explore how these receptors function in liver cells. Patients may benefit from insights that could lead to new treatments for NAFLD and associated conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease or those at risk due to obesity or type 2 diabetes.
Not a fit: Patients with liver diseases caused by alcohol consumption or other non-metabolic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat non-alcoholic fatty liver disease and reduce related health risks.
How similar studies have performed: Previous research has shown promising results in targeting nuclear receptors for metabolic diseases, indicating potential for success in this area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Lazar, Mitchell a. — University of Pennsylvania
- Study coordinator: Lazar, Mitchell a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.