Investigating how specific proteins in immune cells affect inflammation in arthritis
Roles of the Src-Family Kinases LynA and LynB in Macrophage Inflammatory Signaling
This study is looking at how a protein called LynA affects inflammation in kids with juvenile idiopathic arthritis (JIA), with the goal of finding new treatments that can help reduce swelling in their joints without interfering with their immune system's ability to fight off infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10479091 on NIH RePORTER |
What this research studies
This research focuses on juvenile idiopathic arthritis (JIA), a common autoimmune disease in children that leads to joint and bone damage. It examines the role of a protein called LynA in macrophages, which are immune cells that contribute to inflammation. By studying how LynA influences inflammatory signaling without affecting the body's ability to fight infections, the researchers aim to develop targeted therapies that can reduce inflammation specifically in JIA patients. The study involves testing in both animal models and human samples to evaluate the potential for new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with juvenile idiopathic arthritis, particularly those experiencing significant inflammation.
Not a fit: Patients with other types of arthritis or autoimmune diseases unrelated to macrophage signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for JIA that minimize side effects related to immune suppression.
How similar studies have performed: Previous research has shown promise in targeting specific immune pathways to improve treatment outcomes in autoimmune diseases, suggesting this approach could be beneficial.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Freedman, Tanya S. — University of Minnesota
- Study coordinator: Freedman, Tanya S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.