Investigating how specific proteins affect inflammation in immune cells related to arthritis.
Roles of the Src-Family Kinases LynA and LynB in Macrophage Inflammatory Signaling
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-10703861
This study is looking at how a protein called LynA affects immune cells in kids with juvenile idiopathic arthritis, with the goal of finding new treatments that can reduce harmful inflammation without hurting their overall immune system.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10703861 on ClinicalTrials.gov |
What this research studies
This research focuses on juvenile idiopathic arthritis (JIA), a common autoimmune disease in children that leads to joint and bone damage. It examines the role of a protein called LynA in macrophages, which are immune cells that contribute to inflammation in JIA. The study aims to differentiate between harmful inflammatory responses and normal immune functions, potentially leading to new therapies that target only the problematic signaling pathways without compromising overall immune defense. Researchers will analyze macrophages from JIA patients and use mouse models to explore the therapeutic potential of targeting LynA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with juvenile idiopathic arthritis.
Not a fit: Patients with other types of arthritis or autoimmune diseases unrelated to JIA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for JIA that minimize side effects and improve patient outcomes.
How similar studies have performed: Previous research has shown promise in targeting specific inflammatory pathways in autoimmune diseases, suggesting potential success for this novel approach.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREEDMAN, TANYA S. — UNIVERSITY OF MINNESOTA
- Study coordinator: FREEDMAN, TANYA S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder