Investigating how specific microRNAs can reduce lung inflammation in acute respiratory distress syndrome.
Official title: Targeting Myeloid Dependent MicroRNAs in Acute Respiratory Distress Syndrome
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11014421 · Data updated 2026-11-12
This study is looking at how a tiny molecule called microRNA-147 can help control lung inflammation in people with acute respiratory distress syndrome (ARDS), with the goal of finding new ways to reduce this inflammation and improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $390,000 |
| NIH project number | 5R01HL155950-04 |
| Project ID | NIH-11014421 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing acute respiratory distress syndrome or related lung inflammatory conditions.
✕Less likely to help
Patients with chronic respiratory conditions or those not experiencing acute lung inflammation may not benefit from this research.
What this research studies
This research focuses on understanding the role of microRNAs, particularly microRNA-147, in controlling lung inflammation associated with acute respiratory distress syndrome (ARDS). The study aims to identify how these microRNAs can reprogram macrophages, a type of immune cell, to manage excessive inflammation that occurs during ARDS. By examining the mechanisms through which microRNA-147 influences inflammatory cytokine production, the research seeks to develop new therapeutic strategies to mitigate lung inflammation in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that significantly reduce lung inflammation in patients with acute respiratory distress syndrome.
How similar studies have gone: Previous research has shown promising results in targeting microRNAs for inflammatory diseases, suggesting potential success for this approach in ARDS.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Yuan, Xiaoyi — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Yuan, Xiaoyi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.