Investigating how specific brain cells in the nucleus accumbens affect cocaine addiction
Understanding neuronal subtype-specific function of NAc in cocaine addiction
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11034046
This study is looking at how certain brain cells in a part of the brain called the nucleus accumbens affect cocaine addiction, using animal models to see how these cells change when they use cocaine, which could help us find better ways to treat addiction.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11034046 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how different types of neurons in the nucleus accumbens (NAc) contribute to cocaine addiction. By analyzing the gene expression profiles of these neurons, the study aims to uncover the specific cellular mechanisms that lead to addiction and relapse. The approach involves using animal models to simulate cocaine self-administration, allowing researchers to observe changes in behavior and brain function. This could provide insights into the biological basis of addiction and potential targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with cocaine addiction or those at risk of relapse.
Not a fit: Patients who are not addicted to cocaine or who have not previously used cocaine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cocaine addiction that are more effective and targeted.
How similar studies have performed: Previous research has shown promising results in understanding addiction mechanisms through similar approaches, indicating potential for success in this study.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, YI — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: ZHANG, YI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder, Brain Diseases, Brain Disorders