Investigating how specific brain cells contribute to abnormal movements in dystonia.
Cell Type Specific Genetic Manipulation to Dissect Cholinergic Interneuron Function and Plasticity in a Symptomatic Model of DYT1 Dystonia
This study is looking at special brain cells that help control movement to understand why they don't work properly in people with DYT1 dystonia, a condition that causes twisting movements, and the goal is to find new ways to help those affected by similar movement issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11017050 on NIH RePORTER |
What this research studies
This research focuses on cholinergic interneurons, which are important for controlling movement but are not well understood. The study aims to uncover how these neurons malfunction in conditions like DYT1 dystonia, a movement disorder. By using advanced genetic techniques in a mouse model, researchers will explore the cellular mechanisms that lead to abnormal twisting movements. The findings could help identify new treatment strategies for patients suffering from similar motor dysfunctions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with DYT1 dystonia or those experiencing similar abnormal movements.
Not a fit: Patients with movement disorders not related to cholinergic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with DYT1 dystonia and related movement disorders.
How similar studies have performed: Previous research has shown that targeting cholinergic neurons can lead to significant insights into movement disorders, suggesting this approach has potential for success.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Dauer, William T. — Ut Southwestern Medical Center
- Study coordinator: Dauer, William T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.