Investigating how soluble ST2 affects lung injury and recovery
Official title: The Impact of Soluble ST2 on Lung Injury Onset and Resolution
Funded at Massachusetts General Hospital · NIH-11056066 · Data updated 2026-11-12
This study is looking at how a protein called soluble ST2 affects the start and recovery from acute respiratory distress syndrome (ARDS) to help doctors better understand and treat patients with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $170,640 |
| NIH project number | 5K08HL173572-02 |
| Project ID | NIH-11056066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing acute respiratory distress syndrome or related lung injuries.
✕Less likely to help
Patients with chronic lung conditions or those not experiencing acute respiratory distress may not benefit from this research.
What this research studies
This research explores the role of soluble ST2 in the onset and resolution of acute respiratory distress syndrome (ARDS). The project utilizes murine models to study the immune response related to lung injury and aims to develop statistical models to analyze patient data over time. The principal investigator, Dr. Jehan Alladina, will receive training in advanced research techniques and collaborate with experts in lung immunology and biostatistics. The ultimate goal is to enhance understanding of ARDS and improve treatment strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for patients suffering from acute respiratory distress syndrome.
How similar studies have gone: Previous research has shown promise in understanding immune responses in lung injuries, suggesting potential for success in this area.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Alladina, Jehan — Massachusetts General Hospital
- Study coordinator: Alladina, Jehan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.