Investigating how small RNA modifications affect glioma
Official title: The role of small RNA modifications in glioma
Funded at University of Alabama at Birmingham · NIH-10879074 · Data updated 2026-11-12
This study is looking at tiny pieces of RNA in brain cancer called glioma to see how changes in them might affect the cancer's growth and behavior, with the hope of finding new ways to diagnose or treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $209,674 |
| NIH project number | 5R00CA259526-04 |
| Project ID | NIH-10879074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioma or glioblastoma, particularly those who may benefit from novel therapeutic strategies.
✕Less likely to help
Patients with other types of cancer or those without glioma may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the role of small non-coding RNAs, particularly tRNA-related fragments, in glioma, a type of brain cancer. The study aims to explore how modifications to these small RNAs can influence gene expression and contribute to the development and progression of gliomas. By analyzing glioma cell lines and patient samples, the research seeks to identify specific small RNA modifications that may serve as potential biomarkers or therapeutic targets. The approach includes detailed examinations of the biological functions of these modifications and their impact on cancer cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for glioma patients, improving outcomes and survival rates.
How similar studies have gone: While the specific focus on small RNA modifications in glioma is relatively novel, similar approaches in other cancers have shown promising results.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Su, Zhangli — University of Alabama at Birmingham
- Study coordinator: Su, Zhangli
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.