Investigating how Sirt-1 affects inflammation in Kawasaki Disease
Targeting the Sirt-1 pathway to modulate inflammation during murine Kawasaki Disease vasculitis
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10890070
This study is looking at Kawasaki Disease in kids and how a specific pathway in the body might help reduce inflammation in their blood vessels, with hopes of finding better treatments to keep their hearts healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10890070 on ClinicalTrials.gov |
What this research studies
This research focuses on Kawasaki Disease, a serious condition that can lead to heart problems in children. It aims to understand how the Sirt-1 pathway influences inflammation during this disease, particularly in the blood vessels. By studying a mouse model, researchers will explore how Sirt-1 can help reduce harmful inflammation and improve treatment outcomes. The goal is to identify new therapeutic strategies that could benefit children suffering from this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Kawasaki Disease, particularly those who are resistant to standard treatments.
Not a fit: Patients with Kawasaki Disease who respond well to existing treatments may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Kawasaki Disease, reducing the risk of long-term heart complications in affected children.
How similar studies have performed: Previous research has shown promising results in targeting inflammatory pathways in similar conditions, suggesting potential for success in this approach.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOVAL RIVAS, MAGALI — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: NOVAL RIVAS, MAGALI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease