Investigating how Sirt-1 affects inflammation in Kawasaki Disease
Official title: Targeting the Sirt-1 pathway to modulate inflammation during murine Kawasaki Disease vasculitis
Funded at Cedars-Sinai Medical Center · NIH-10890070 · Data updated 2026-11-12
This study is looking at Kawasaki Disease in kids and how a specific pathway in the body might help reduce inflammation in their blood vessels, with hopes of finding better treatments to keep their hearts healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $417,500 |
| NIH project number | 5R01HL159297-04 |
| Project ID | NIH-10890070 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Kawasaki Disease, particularly those who are resistant to standard treatments.
✕Less likely to help
Patients with Kawasaki Disease who respond well to existing treatments may not benefit from this specific research.
What this research studies
This research focuses on Kawasaki Disease, a serious condition that can lead to heart problems in children. It aims to understand how the Sirt-1 pathway influences inflammation during this disease, particularly in the blood vessels. By studying a mouse model, researchers will explore how Sirt-1 can help reduce harmful inflammation and improve treatment outcomes. The goal is to identify new therapeutic strategies that could benefit children suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Kawasaki Disease, reducing the risk of long-term heart complications in affected children.
How similar studies have gone: Previous research has shown promising results in targeting inflammatory pathways in similar conditions, suggesting potential for success in this approach.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Noval Rivas, Magali — Cedars-Sinai Medical Center
- Study coordinator: Noval Rivas, Magali
Related research
Other NIH-funded projects on the same topics.
-
Gut bacteria and permeability linked to Kawasaki disease in kids
A pediatric-focused study exploring how the gut microbiome and intestinal barrier may influence Kawasaki disease and its inflammation.
-
Role of sex in immune-stromal cell interactions driving Kawasaki disease vasculitis
This project looks at why Kawasaki disease causes heart problems in kids and how sex differences affect the immune cell interactions that lead to artery inflammation.
-
Sex differences in immune–vessel cell interactions in Kawasaki disease
This project looks at how being male or female changes immune and blood-vessel cell behavior that leads to coronary artery damage in people with Kawasaki disease.
-
Gut bacteria and 'leaky' gut in Kawasaki disease
This research looks at whether changes in gut bacteria and a 'leaky' gut make Kawasaki disease worse in young children.
-
Investigating how sex affects immune interactions in Kawasaki disease
This study is looking at how Kawasaki disease affects kids and how the immune system interacts with blood vessels differently in boys and girls, with the goal of finding better treatments for those who don’t respond to regular therapies.
-
FcgR-activated neutrophils shaping T cells in kidney and vessel inflammation
This NIH grant explores how a specific neutrophil behavior may drive harmful T-cell activity in lupus-related kidney inflammation and vasculitis, with potential to inform new treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.