Investigating how sex hormone receptors affect brain cancers
Official title: Understanding expression and signaling of sex hormone receptors in brain cancers
Funded at University of California, San Francisco · NIH-10990437 · Data updated 2026-11-12
This study is looking at how certain hormone receptors in the brain might affect the growth of tumors like meningiomas and glioblastomas, especially in women, to help find better treatments for people with these types of brain cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,717 |
| NIH project number | 1F99CA294312-01 |
| Project ID | NIH-10990437 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with meningiomas or glioblastomas, particularly those who are female or have a history of hormone therapy.
✕Less likely to help
Patients with brain cancers that do not express sex hormone receptors or those with other types of CNS tumors may not benefit from this research.
What this research studies
This research focuses on understanding the role of sex hormone receptors in central nervous system (CNS) tumors, particularly meningiomas and glioblastomas. It aims to uncover how these receptors influence tumor growth and behavior, especially in relation to female sex hormones. By using human tumor models in mice, the study will explore the mechanisms by which hormone signaling may contribute to cancer development and progression. This could lead to new insights into targeted therapies for patients with these types of brain cancers.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with brain cancers influenced by sex hormones.
How similar studies have gone: Previous research has shown promising results in understanding the role of sex hormones in other cancers, suggesting potential for success in this area as well.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Dwyer Cady, Martha Addison — University of California, San Francisco
- Study coordinator: Dwyer Cady, Martha Addison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.