Investigating how sex chromosomes affect Alzheimer's disease
Official title: Systematic investigation of genetic contributions of sex chromosomes to Alzheimer's disease
Funded at Arizona State University-Tempe Campus · NIH-11053812 · Data updated 2026-11-12
This study is looking at how differences in the X and Y chromosomes might affect Alzheimer's disease, helping us understand why men and women may experience it differently, and the results will be shared to help improve future research.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $425,501 |
| NIH project number | 1R21AG091567-01 |
| Project ID | NIH-11053812 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those who may have a family history of the condition.
✕Less likely to help
Patients without a diagnosis of Alzheimer's disease or those who do not have genetic variations related to sex chromosomes may not benefit from this research.
What this research studies
This research focuses on understanding the role of sex chromosomes in Alzheimer's disease by analyzing genetic data from large clinical cohorts. The team will use advanced techniques to realign next-generation sequencing data, specifically looking at how variations in the X and Y chromosomes relate to Alzheimer's disease symptoms. By examining gene expression and network analysis, the study aims to uncover the genetic factors that contribute to differences in Alzheimer's disease between sexes. The findings will be shared publicly to enhance scientific knowledge and future research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for Alzheimer's disease that take into account genetic differences between sexes.
How similar studies have gone: While the investigation of sex chromosomes in Alzheimer's disease is a relatively novel approach, previous research has shown that genetic factors significantly influence disease outcomes, suggesting potential for success.
Where this research is happening
-
Arizona State University-Tempe Campus
Tempe, United States Active
Researchers
- Principal investigator: Wang, Qi — Arizona State University-Tempe Campus
- Study coordinator: Wang, Qi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.