Investigating how sex affects recovery after knee injuries
Sex-based Muscular Adaptations, Capillary dysfunction and functional decline impact Knee-related psychosocial outcomes after acute knee injury (SMACK)
This study is looking at how men and women recover differently after an ACL injury and surgery, focusing on how biological factors might affect muscle healing and overall recovery, with the goal of creating better rehab plans specifically for women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-11090346 on NIH RePORTER |
What this research studies
This research focuses on understanding the differences in recovery outcomes between males and females following an Anterior Cruciate Ligament (ACL) injury and reconstruction. It aims to explore how biological factors related to sex influence muscle recovery, knee function, and psychosocial outcomes. By examining the cellular and molecular differences in muscle function, the study seeks to identify specific challenges faced by females during recovery. The findings could lead to tailored rehabilitation strategies that improve recovery for women after ACL injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ACL injury and are undergoing or have undergone ACL reconstruction, particularly females.
Not a fit: Patients who have not sustained an ACL injury or those who are male may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies specifically designed for women after ACL injuries, enhancing their physical and psychosocial outcomes.
How similar studies have performed: Previous research has indicated that sex-based differences exist in recovery outcomes after ACL injuries, suggesting that this approach is both relevant and necessary.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Noehren, Brian — University of Kentucky
- Study coordinator: Noehren, Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.