Investigating how roseoloviruses may trigger autoimmune diseases
Official title: Establishing the impact of roseolovirues on development of autoimmunity due to loss of central tolerance
Funded at Washington University · NIH-10893935 · Data updated 2026-11-12
This study is looking at how certain viruses might play a role in causing autoimmune diseases by affecting the immune system, and it could help people understand new ways to prevent or treat these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $197,912 |
| NIH project number | 5K08AI168495-02 |
| Project ID | NIH-10893935 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with autoimmune diseases or those with a history of roseolovirus infections.
✕Less likely to help
Patients without autoimmune diseases or those not exposed to roseoloviruses may not receive direct benefits from this research.
What this research studies
This research explores the relationship between roseoloviruses and the development of autoimmune diseases, particularly focusing on how these viruses may disrupt the body's central tolerance mechanisms. The study involves examining the effects of murine roseolovirus on specific immune cells in neonatal models, which may lead to the development of autoimmune conditions later in life. By analyzing changes in immune cell populations and their functions, the research aims to uncover the underlying mechanisms that link viral infections to autoimmunity. Patients may benefit from insights gained into how these viruses contribute to autoimmune diseases, potentially leading to new prevention or treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of autoimmune diseases linked to viral infections.
How similar studies have gone: Previous research has suggested a link between roseoloviruses and autoimmune diseases, but this specific approach to understanding the mechanisms is relatively novel.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Bigley, Tarin M — Washington University
- Study coordinator: Bigley, Tarin M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.