Investigating how RNA helicase Ddx5 affects heart failure
Official title: Role of RNA helicase Ddx5 in pathological cardiac remodeling
Funded at University of Wisconsin-Madison · NIH-11092103 · Data updated 2026-11-12
This study is looking at a protein called Ddx5 to see how it affects heart health in people with heart failure, and it hopes to find new ways to help treat this condition by examining heart tissue from patients and animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | November 15, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $527,982 |
| NIH project number | 5R01HL170132-04 |
| Project ID | NIH-11092103 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with heart failure or those at risk for developing heart-related conditions.
✕Less likely to help
Patients with non-cardiac related health issues or those without any heart conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific protein, RNA helicase Ddx5, in heart failure, a serious condition affecting many people worldwide. The study will explore how Ddx5 regulates RNA processes that are crucial for heart function, particularly in the context of heart disease. By examining heart tissue from patients and animal models, researchers aim to uncover how disruptions in Ddx5 may lead to heart problems, potentially paving the way for new treatments. Patients may be involved in providing heart tissue samples or participating in related clinical assessments.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating heart failure by targeting RNA regulation.
How similar studies have gone: Other research has shown promising results in understanding RNA regulation in heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Topkara, Veli Kemal — University of Wisconsin-Madison
- Study coordinator: Topkara, Veli Kemal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.