Investigating how RNA editing affects coronary artery disease
Official title: ADAR mediated RNA editing is a causal mechanism in coronary artery disease
Funded at Stanford University · NIH-10896909 · Data updated 2026-11-12
This study is looking at how changes in RNA might affect the risk of coronary artery disease, which is a major health issue, and aims to find new ways to treat it by understanding the genetics behind it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $165,996 |
| NIH project number | 5K08HL167699-02 |
| Project ID | NIH-10896909 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a genetic predisposition to coronary artery disease or those experiencing related cardiovascular issues.
✕Less likely to help
Patients without any genetic risk factors for coronary artery disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of RNA editing in coronary artery disease (CAD), which is a leading cause of death globally. By studying the mechanisms behind RNA editing mediated by ADAR enzymes, the research aims to uncover how genetic variations influence CAD risk. The approach involves leveraging human genetics and advanced techniques like CRISPR to explore potential therapeutic targets, particularly the MDA5 sensor involved in vascular inflammation. Patients may benefit from new treatment strategies developed from these insights.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that significantly reduce the risk and impact of coronary artery disease.
How similar studies have gone: Other research has shown promising results in understanding genetic mechanisms of coronary artery disease, but the specific focus on ADAR mediated RNA editing is relatively novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Weldy, Chad S — Stanford University
- Study coordinator: Weldy, Chad S
Related research
Other NIH-funded projects on the same topics.
-
ADAR RNA editing and coronary artery disease: a pathway to new therapies
A scientist-led study at Stanford investigates how changes in RNA editing by ADAR enzymes may drive coronary artery disease and how targeting related pathways could lead to new treatments.
-
ZEB1's role in artery disease and smooth muscle cell changes
This grant studies how the ZEB1 gene affects coronary artery disease by its impact on smooth muscle cells in blood vessels.
-
New imaging methods to improve coronary artery disease diagnosis with dynamic PET
A new PET imaging approach is being tested to measure heart blood flow more accurately in people with suspected coronary artery disease.
-
Understanding why some people with type 1 diabetes get or avoid major heart disease due to genetics
A study looks at genetic factors and immune-related markers to understand why some young people with type 1 diabetes develop major heart disease and others don’t.
-
Multimodal genetic regulation in coronary artery disease
A research grant using advanced genetic and cellular analyses to understand what drives coronary artery disease in diverse populations.
-
Smooth muscle cell programs for coronary artery disease
Researchers are studying how specific gene changes in smooth muscle cells influence coronary artery disease to identify new ways to prevent or treat the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.