Investigating how RNA editing affects coronary artery disease
ADAR mediated RNA editing is a causal mechanism in coronary artery disease
This study is looking at how changes in RNA might affect the risk of coronary artery disease, which is a major health issue, and aims to find new ways to treat it by understanding the genetics behind it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10896909 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of RNA editing in coronary artery disease (CAD), which is a leading cause of death globally. By studying the mechanisms behind RNA editing mediated by ADAR enzymes, the research aims to uncover how genetic variations influence CAD risk. The approach involves leveraging human genetics and advanced techniques like CRISPR to explore potential therapeutic targets, particularly the MDA5 sensor involved in vascular inflammation. Patients may benefit from new treatment strategies developed from these insights.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a genetic predisposition to coronary artery disease or those experiencing related cardiovascular issues.
Not a fit: Patients without any genetic risk factors for coronary artery disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that significantly reduce the risk and impact of coronary artery disease.
How similar studies have performed: Other research has shown promising results in understanding genetic mechanisms of coronary artery disease, but the specific focus on ADAR mediated RNA editing is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Weldy, Chad S — Stanford University
- Study coordinator: Weldy, Chad S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.