Investigating how rheumatoid arthritis affects heart disease risk and identifying biomarkers.
Official title: Rheumatoid Arthritis and the Risk of Cardiovascular Disease: Biomarkers Risk Prediction and Underlying Mechanisms
Funded at Brigham and Women's Hospital · NIH-11103158 · Data updated 2026-11-12
This study is looking at how inflammation from rheumatoid arthritis might raise the risk of heart problems, and it aims to find specific proteins in the blood that can help predict this risk better, so that people with RA can get earlier help to protect their hearts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 15, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $603,179 |
| NIH project number | 5R01HL163580-04 |
| Project ID | NIH-11103158 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who may be at risk for cardiovascular disease.
✕Less likely to help
Patients without rheumatoid arthritis or those who do not have any cardiovascular risk factors may not benefit from this research.
What this research studies
This research focuses on understanding the connection between rheumatoid arthritis (RA) and cardiovascular disease (CVD), particularly how inflammation in RA patients may increase their risk of heart attacks and strokes. The study aims to identify specific protein biomarkers that can predict CVD risk in RA patients more accurately than current methods. By analyzing blood samples and immune profiles, researchers hope to develop a reliable risk score that can help in early detection and prevention strategies for heart disease in these patients.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and prevention strategies for cardiovascular disease in patients with rheumatoid arthritis.
How similar studies have gone: Previous research has shown promising results in identifying biomarkers related to cardiovascular disease in inflammatory conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Solomon, Daniel Hal — Brigham and Women's Hospital
- Study coordinator: Solomon, Daniel Hal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.