Investigating how regulatory T cells affect pulmonary hypertension
Regulatory T Cells and Pulmonary Hypertension
This study is looking at how certain immune cells called regulatory T cells might help improve pulmonary arterial hypertension (PAH) by fixing their problems and reducing inflammation, with the hope of finding new treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Palo Alto Veterans Instit for Research NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project ID | NIH-10897069 on NIH RePORTER |
What this research studies
This research explores the role of regulatory T cells (Tregs) in the development and progression of pulmonary arterial hypertension (PAH). It examines how abnormalities in Tregs, influenced by genetic factors and inflammation, can lead to this serious condition. The study involves infusing corrected Tregs into animal models to restore immune function and reduce vascular inflammation, potentially reversing PAH symptoms. By understanding these mechanisms, the research aims to pave the way for new therapies for patients suffering from PAH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those with autoimmune components.
Not a fit: Patients without pulmonary arterial hypertension or those whose condition is not influenced by regulatory T cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore immune function and alleviate symptoms of pulmonary hypertension.
How similar studies have performed: Other clinical trials involving Treg infusion for autoimmune and inflammatory conditions have shown early promise, suggesting potential success for similar approaches in treating PAH.
Where this research is happening
Palo Alto, United States
- Palo Alto Veterans Instit for Research — Palo Alto, United States (Active)
Researchers
- Principal investigator: Nicolls, Mark Robert — Palo Alto Veterans Instit for Research
- Study coordinator: Nicolls, Mark Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.