Investigating how rare genetic changes affect mental health and cognitive abilities
Large-Scale Evaluation of the Effect of Rare Genetic Variants on Psychiatric Symptoms and Cognitive Ability
This study is looking at how certain rare genetic changes might affect mental health and thinking skills, and it's for people who want to understand more about how their genes could influence their psychiatric symptoms and cognitive abilities.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10610393 on NIH RePORTER |
What this research studies
This research explores the impact of rare genetic variants, specifically copy number variants (CNVs), on psychiatric symptoms and cognitive abilities. By examining these genetic changes, the study aims to uncover underlying mechanisms of mental health disorders that may not be apparent through traditional assessments. Participants will be evaluated to understand how these genetic factors influence their mental health and cognitive functioning, potentially leading to more tailored interventions. The research will involve analyzing data from diverse populations to gain a comprehensive understanding of the effects of these genetic variants.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with diagnosed psychiatric disorders or cognitive impairments, particularly those with a family history of mental health issues.
Not a fit: Patients without any psychiatric symptoms or cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for individuals with mental health disorders based on their genetic profiles.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between genetic variants and psychiatric disorders, indicating that this approach has potential for significant insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Glahn, David C — Boston Children's Hospital
- Study coordinator: Glahn, David C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.