Investigating how RAMS11 affects colorectal cancer progression and treatment resistance
The role of RAMS11 in colorectal cancer progression and treatment resistance
This study is looking at a special RNA called RAMS11 to see how it affects colorectal cancer and how well patients respond to treatments, with the hope of finding ways to better tailor therapies for people after surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11064559 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific RNA molecule, RAMS11, in the progression of colorectal cancer (CRC) and its resistance to treatments. By analyzing tissue samples from patients with both primary and metastatic CRC, the study aims to identify molecular markers that can help stratify patients who may benefit from additional therapies after surgery. The approach includes advanced sequencing techniques to uncover how RAMS11 influences cancer behavior and patient outcomes. Ultimately, the goal is to improve treatment decisions based on individual molecular profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with early-stage colorectal cancer who are at high risk for metastasis.
Not a fit: Patients with late-stage metastatic colorectal cancer who have already exhausted treatment options may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for colorectal cancer patients, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in using molecular profiling to guide cancer treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Maher, Christopher a — Washington University
- Study coordinator: Maher, Christopher a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.