Investigating how Rac1 affects kidney cell repair and structure
Official title: Rac1 and the actin cytoskeleton in renal tubular repair
Funded at Vanderbilt University Medical Center · NIH-11092230 · Data updated 2026-11-12
This study is looking at how a protein called Rac1 helps kidney cells heal after they've been injured, with the hope that understanding this process can lead to better ways to support kidney recovery for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $158,544 |
| NIH project number | 5K08DK134879-03 |
| Project ID | NIH-11092230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute kidney injuries or conditions affecting kidney function.
✕Less likely to help
Patients with chronic kidney disease not related to acute injuries may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the role of Rac1, a key protein, in the repair of kidney cells after injury. It examines how Rac1 influences the organization of the actin cytoskeleton, which is crucial for maintaining the shape and function of kidney cells. By studying the processes involved in cell division and repair, the research aims to uncover mechanisms that could improve kidney health and function. Patients may benefit from insights gained about how to enhance kidney repair following acute injuries.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving kidney repair and function in patients with acute kidney injuries.
How similar studies have gone: Previous research has shown promising results in understanding the role of actin cytoskeleton dynamics in cell repair, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Bock, Fabian Maximilian — Vanderbilt University Medical Center
- Study coordinator: Bock, Fabian Maximilian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.