Investigating how Protocadherin-17 affects visual circuit development in zebrafish
Official title: The role of Protocadherin-17 in the development of direction selective circuits in the zebrafish visual system
Funded at Ohio State University · NIH-10582919 · Data updated 2026-11-12
This study is looking at how a protein called Protocadherin-17 helps zebrafish develop their eyesight, and by understanding this, researchers hope to learn more about how similar issues might affect vision in people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 30, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $433,125 |
| NIH project number | 1R21EY034706-01 |
| Project ID | NIH-10582919 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young individuals experiencing visual processing disorders or related neurological conditions.
✕Less likely to help
Patients with fully developed visual systems and no history of visual processing issues may not benefit from this research.
What this research studies
This research explores the role of Protocadherin-17, a cell adhesion molecule, in the development of visual circuits in zebrafish. By studying zebrafish mutants lacking this protein, researchers aim to understand how the absence of Protocadherin-17 affects the growth of neurons and the formation of synapses during early development. The study will track changes in visual responses and the growth of axons and dendrites, providing insights into the mechanisms behind visual processing disorders. This work could lead to a better understanding of how similar processes might affect human visual systems.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of visual processing disorders and potentially inform future treatments.
How similar studies have gone: While the specific role of Protocadherin-17 in visual circuit development is being explored for the first time, similar studies on cell adhesion molecules have shown promise in understanding neural development.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Jontes, James David — Ohio State University
- Study coordinator: Jontes, James David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.