Investigating how proteins function and behave in biological systems.
Official title: Studies of the function of membrane and soluble proteins and their biophysical properties.
Funded at University of Chicago · NIH-11034121 · Data updated 2026-11-12
This study is all about figuring out how proteins work in our bodies, especially how they fold, move important substances in and out of cells, and react to stress, using advanced computer techniques to help us understand these important processes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $473,655 |
| NIH project number | 5R35GM148233-03 |
| Project ID | NIH-11034121 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions linked to protein misfolding or dysfunction, such as certain neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein function or those not affected by protein misfolding may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the complex behaviors of membrane proteins and other challenging biological systems using advanced computational methods. The Sosnick lab aims to explore how proteins fold, how they transport metabolites across cell membranes, and how they respond to stress. By employing techniques like hydrogen exchange, the research seeks to uncover the dynamics and properties of proteins that are crucial for various biological functions. Collaborative efforts with other labs enhance the depth and applicability of the findings.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding protein functions, which may improve treatments for diseases related to protein misfolding and dysfunction.
How similar studies have gone: Previous research in biophysical chemistry has shown success in understanding soluble proteins, but this approach to membrane proteins and complex systems is relatively novel.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Sosnick, Tobin R — University of Chicago
- Study coordinator: Sosnick, Tobin R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.