Investigating how proteins behave in cells to understand diseases like cancer and autoimmune disorders
Official title: Cellular FM-radios: seeing, probing, and perturbing single-cell protein activity dynamics in biological systems with frequency-barcoded spatiotemporal signaling circuits
Funded at University of Wisconsin-Madison · NIH-10685132 · Data updated 2026-11-12
This study is all about figuring out how proteins work inside our cells, which is really important for things like fighting off illness and healing, and it's designed for anyone interested in understanding more about diseases like cancer and autoimmune disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,399,500 |
| NIH project number | 1DP2GM154329-01 |
| Project ID | NIH-10685132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases or cancers that may benefit from a deeper understanding of cellular protein dynamics.
✕Less likely to help
Patients with conditions unrelated to protein activity dynamics or those not diagnosed with autoimmune diseases or cancers may not benefit from this research.
What this research studies
This research focuses on understanding the dynamics of protein activities within cells, which are crucial for various biological processes such as immune response and healing. By developing innovative 'cellular radio' circuits, researchers aim to visualize and manipulate these protein activities in real-time. This approach allows for detailed observation of how proteins function and interact in both healthy and diseased cells, particularly in the context of cancer and autoimmune diseases. The methodology involves genetically encoding signals that can be tracked and analyzed, providing insights into cellular behavior.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating diseases related to protein dysregulation, such as cancer and autoimmune disorders.
How similar studies have gone: While the approach of using cellular radio circuits is innovative, similar methodologies in studying protein dynamics have shown promise in other research contexts.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Coyle, Scott M. — University of Wisconsin-Madison
- Study coordinator: Coyle, Scott M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.