Investigating how protein processes affect lung injury in ARDS
Systematic Investigation of Protein Ubiquitination in ARDS
This study is looking at how a process that helps break down proteins in the body might affect lung injuries in people with Acute Respiratory Distress Syndrome (ARDS), especially when bacterial infections are involved, to find new ways to help patients breathe better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10749014 on NIH RePORTER |
What this research studies
This research focuses on Acute Respiratory Distress Syndrome (ARDS), a serious condition affecting many patients each year. It aims to understand the role of protein ubiquitination, a process that marks proteins for degradation, in the development of lung injury associated with ARDS. By examining how bacterial infections disrupt this process, the research seeks to identify new therapeutic targets that could improve patient outcomes. The approach involves analyzing the molecular pathways related to protein processing and their impact on inflammation and lung function.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Acute Respiratory Distress Syndrome, particularly those with pneumonia or sepsis.
Not a fit: Patients with ARDS caused by non-infectious factors or those who do not meet the specific inclusion criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the morbidity and mortality associated with ARDS.
How similar studies have performed: While the investigation of protein ubiquitination in ARDS is a novel approach, similar studies have shown promise in understanding other inflammatory diseases.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Chen, Beibei — University of Pittsburgh at Pittsburgh
- Study coordinator: Chen, Beibei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.