Investigating how problems in the cerebellum affect behavior and cognition
Behavioral and brain network effects of dysfunction in the cognitive cerebellum
This study is looking at how a part of the brain called the cerebellum affects thinking and behavior in people with conditions like autism, schizophrenia, and ADHD, and it aims to find out why some people have trouble changing their learned behaviors.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project ID | NIH-10651608 on NIH RePORTER |
What this research studies
This research explores the role of the cerebellum, a part of the brain, in cognitive disorders such as autism, schizophrenia, and ADHD. It aims to understand how dysfunction in specific cerebellar regions can lead to difficulties in adapting learned behaviors. By examining the communication between the cerebellum and other brain areas, the study seeks to identify the mechanisms behind behavioral inflexibility. Patients may be involved in assessments to help researchers gather data on these cognitive processes.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with autism spectrum disorder, schizophrenia, or ADHD who are over 21 years old.
Not a fit: Patients with cognitive disorders not related to cerebellar dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for cognitive disorders that affect behavior flexibility.
How similar studies have performed: Previous studies have indicated that cerebellar dysfunction is linked to cognitive disorders, suggesting that this research builds on established findings.
Where this research is happening
Torrance, United States
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center — Torrance, United States (Active)
Researchers
- Principal investigator: Mathews, Paul James — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Mathews, Paul James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.