Investigating how pneumonia affects lung function at the capillary level
Probing immunovascular mechanobiology in pneumonia-associated acute lung injury at the single capillary level
['FUNDING_FELLOWSHIP'] · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · NIH-11061224
This study is looking at how lung injuries from pneumonia affect breathing and the immune system, using special imaging to see how immune cells and blood flow work in real-time, with the hope of finding better ways to help people with acute respiratory distress syndrome (ARDS).
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11061224 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding acute respiratory distress syndrome (ARDS) and acute lung injury (ALI), which can occur due to pneumonia. It aims to explore how damage to the lung's tiny blood vessels and air sacs affects breathing and immune responses. By using advanced imaging techniques, the study will observe the behavior of immune cells and blood flow in real-time, providing insights into the mechanics of lung injury. This could lead to better therapeutic strategies for managing ARDS and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with acute respiratory distress syndrome or acute lung injury due to pneumonia.
Not a fit: Patients with chronic lung diseases or those not affected by pneumonia-related lung injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from pneumonia-related lung injuries.
How similar studies have performed: While the study addresses a critical gap in understanding ARDS, similar research approaches have shown promise in other areas of lung mechanics and immune response.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHI, LINZHENG — BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- Study coordinator: SHI, LINZHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome