Investigating how pneumonia affects lung function at the capillary level
Official title: Probing immunovascular mechanobiology in pneumonia-associated acute lung injury at the single capillary level
Funded at Boston University (Charles River Campus) · NIH-11061224 · Data updated 2026-11-12
This study is looking at how lung injuries from pneumonia affect breathing and the immune system, using special imaging to see how immune cells and blood flow work in real-time, with the hope of finding better ways to help people with acute respiratory distress syndrome (ARDS).
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30HL168952-03 |
| Project ID | NIH-11061224 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with acute respiratory distress syndrome or acute lung injury due to pneumonia.
✕Less likely to help
Patients with chronic lung diseases or those not affected by pneumonia-related lung injuries may not benefit from this research.
What this research studies
This research focuses on understanding acute respiratory distress syndrome (ARDS) and acute lung injury (ALI), which can occur due to pneumonia. It aims to explore how damage to the lung's tiny blood vessels and air sacs affects breathing and immune responses. By using advanced imaging techniques, the study will observe the behavior of immune cells and blood flow in real-time, providing insights into the mechanics of lung injury. This could lead to better therapeutic strategies for managing ARDS and improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from pneumonia-related lung injuries.
How similar studies have gone: While the study addresses a critical gap in understanding ARDS, similar research approaches have shown promise in other areas of lung mechanics and immune response.
Where this research is happening
-
Boston University (Charles River Campus)
Boston, United States Active
Researchers
- Principal investigator: Shi, Linzheng — Boston University (Charles River Campus)
- Study coordinator: Shi, Linzheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.