Investigating how oxidative stress affects insulin-producing cells in Type 1 diabetes
Beta-cell responses to oxidative stress and Type 1 diabetes
This study is looking at how oxidative stress affects the insulin-producing cells in people with Type 1 diabetes, using mice to see if reducing this stress can help protect these cells, and it will also test if an antioxidant treatment can support human pancreatic cells, all with the hope of finding new ways to delay or prevent Type 1 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10860959 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of oxidative stress in the destruction of insulin-producing beta cells in Type 1 diabetes (T1D). By comparing two types of mice—one that is prone to T1D and another that is resistant due to a genetic modification that reduces oxidative stress—the researchers aim to uncover how the absence of reactive oxygen species (ROS) influences beta cell function and immune interactions. Additionally, the study will explore the effects of antioxidant treatment on human pancreatic islets to see if it can help preserve beta cell function. The goal is to identify potential therapeutic strategies that could delay or prevent the onset of T1D.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of developing Type 1 diabetes or those who have recently been diagnosed.
Not a fit: Patients with Type 2 diabetes or other forms of diabetes unrelated to autoimmune processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that preserve insulin production in patients with Type 1 diabetes.
How similar studies have performed: Previous research has shown promising results in using antioxidants to protect beta cells, suggesting that this approach may be effective.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Tse, Hubert M — University of Kansas Medical Center
- Study coordinator: Tse, Hubert M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.