Investigating how obesity contributes to pancreatic cancer and ways to prevent it
Official title: Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma
Funded at University of California Los Angeles · NIH-10832001 · Data updated 2026-11-12
This study is looking at how being overweight can lead to pancreatic cancer, and it’s for anyone interested in understanding this link better, as well as finding ways to prevent the disease using new treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | May 1, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,088,453 |
| NIH project number | 5P01CA236585-05 |
| Project ID | NIH-10832001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are obese and at risk for pancreatic cancer.
✕Less likely to help
Patients who are not obese or those who already have advanced pancreatic cancer may not benefit from this research.
What this research studies
This research focuses on understanding the biological mechanisms by which obesity promotes the development of pancreatic cancer. It involves a collaborative effort from experts at UCLA and Cedars Sinai Medical Center, utilizing innovative animal and cell culture models to explore how factors like adipose tissue inflammation and the pancreatic microenvironment contribute to cancer risk. The program aims to develop effective prevention strategies, including the use of lipid-lowering and antidiabetic agents, to combat this serious disease.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for pancreatic cancer, particularly for individuals affected by obesity.
How similar studies have gone: Previous research has shown promise in understanding the links between obesity and various cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Eibl, Guido Erwin Michael — University of California Los Angeles
- Study coordinator: Eibl, Guido Erwin Michael
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This project will try to change inflammatory, scar-forming cells around pancreatic tumors so treatments and the immune system can work better for people with pancreatic ductal adenocarcinoma.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.