Investigating how Notch signaling affects heart disease in type 2 diabetes.
Official title: The Role of Notch Signaling in Type 2 Diabetic Coronary Microvascular Disease
Funded at Research Inst Nationwide Children's Hosp · NIH-11021021 · Data updated 2026-11-12
This study is looking at how heart disease develops in people with type 2 diabetes, especially how tiny blood vessels in the heart can cause problems with blood flow and increase the risk of heart attacks, and it aims to find new ways to help improve heart health for those living with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $547,566 |
| NIH project number | 5R01HL165124-03 |
| Project ID | NIH-11021021 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with type 2 diabetes who are at risk for cardiovascular disease.
✕Less likely to help
Patients without type 2 diabetes or those with other unrelated cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind heart disease in patients with type 2 diabetes, particularly how coronary microvascular disease contributes to impaired blood flow and increased risk of heart attacks. The study examines the role of Notch signaling, a pathway that facilitates communication between different types of cells in the blood vessels. By using animal models, researchers will explore how changes in this signaling pathway may lead to structural changes in the coronary microvessels, ultimately affecting heart health. The goal is to uncover potential targets for new treatments that could improve cardiovascular outcomes for diabetic patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart health and reduce the risk of heart attacks in patients with type 2 diabetes.
How similar studies have gone: Previous studies have shown promising results in understanding the role of signaling pathways in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
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Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Trask, Aaron J — Research Inst Nationwide Children's Hosp
- Study coordinator: Trask, Aaron J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.