Investigating how NOS3 and p38 MAP kinase interact and regulate each other
Official title: NOS3 and p38 MAP kinase - is the interaction between them a mechanism of p38 regulation?
Funded at Kennesaw State University · NIH-10653595 · Data updated 2026-11-12
This study is looking at how two important proteins in our bodies work together, which could help us find new ways to treat diseases like heart problems, diabetes, and cancer.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kennesaw State University NIH-funded |
| Lab location | 1 site (Kennesaw, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $405,650 |
| NIH project number | 1R15GM147866-01A1 |
| Project ID | NIH-10653595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with atherosclerosis, diabetes, or certain types of cancer.
✕Less likely to help
Patients with conditions unrelated to vascular signaling or those not affected by NOS3 or p38 MAP kinase may not benefit from this research.
What this research studies
This research explores the interaction between Nitric Oxide Synthase 3 (NOS3) and p38 MAP kinase, two important proteins involved in cellular signaling. By examining how these proteins bind and influence each other's activity, the research aims to uncover mechanisms that could impact diseases such as atherosclerosis, diabetes, and cancer. The study will utilize advanced techniques like proximity ligation assays and biolayer interferometry to analyze these interactions in both laboratory settings and within living cells. This could lead to a better understanding of how to regulate these proteins for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cardiovascular diseases and other conditions linked to NOS3 and p38 MAP kinase dysfunction.
How similar studies have gone: While the specific interaction between NOS3 and p38 MAP kinase is being explored in this research, similar studies have shown promise in understanding protein interactions in cellular signaling.
Where this research is happening
-
Kennesaw State University
Kennesaw, United States Active
Researchers
- Principal investigator: Chrestensen, Carol Ann — Kennesaw State University
- Study coordinator: Chrestensen, Carol Ann
Related research
Other NIH-funded projects on the same topics.
-
Smartphone retinal imaging for diabetic eye disease in Egypt
This project uses a low-cost smartphone camera and AI to find signs of diabetic eye damage in adults with diabetes in Egypt.
-
Deep learning to predict obstruction site and guide sleep apnea treatment
A patient-focused project uses snoring sounds and AI to predict where your airway collapses during sleep and to guide personalized treatments.
-
PFAS chemicals may boost mosquito problems and disease risk
This grant tests how common water pollutants called PFAS affect mosquitoes and their ability to spread diseases.
-
Broad-spectrum antiparasitic targets in apicomplexan parasites
Researchers will study parasite enzymes essential for their cell membranes to find new drug targets that could help treat malaria and other infections.
-
Discovery of how Pseudomonas aeruginosa controls its genes and antibiotic resistance
Researchers will use a new method to uncover how a common pathogen switches on genes that help it cause infections and resist antibiotics, with the goal of informing future treatments.
-
Portable optical brain screen to spot stroke risk in Ugandan children with sickle cell disease
A new, affordable optical device used with a mobile system aims to quickly identify young children with sickle cell disease who are at risk of stroke in Uganda.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.