Investigating how NLRP3 affects immune cell regulation in the gut
Official title: Function of NLRP3 in regulatory T cell-mediated control of intestinal homeostasis
Funded at University of California, San Diego · NIH-10884222 · Data updated 2026-11-12
This study is looking at how a protein called NLRP3 affects a type of immune cell in the intestines that helps keep our immune system balanced and prevents inflammation, which could be helpful for people dealing with gut issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $41,567 |
| NIH project number | 5F31DK135162-02 |
| Project ID | NIH-10884222 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune disorders or inflammatory bowel diseases who may benefit from improved immune regulation.
✕Less likely to help
Patients with non-autoimmune related gastrointestinal issues or those without any inflammatory conditions may not receive direct benefits from this research.
What this research studies
This research explores the role of a protein complex called NLRP3 in regulating a specific type of immune cell known as regulatory T cells (Tregs) within the intestines. By examining how NLRP3 influences Treg function, the study aims to understand its impact on maintaining a balanced immune response and preventing inflammation in the gut. The researchers will use various experimental techniques to manipulate and observe the behavior of Tregs in both healthy and diseased states, providing insights into the mechanisms that govern intestinal health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases and inflammatory conditions affecting the gut.
How similar studies have gone: Previous studies have shown promising results regarding the role of inflammasomes in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Patkar, Rasika — University of California, San Diego
- Study coordinator: Patkar, Rasika
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.