Investigating how Neuropeptide S affects sleep and anxiety
Neuropeptide S and arousal
This study is looking at how a special brain chemical called Neuropeptide S affects sleep and wakefulness, especially in relation to anxiety, using specially designed mice to help us understand sleep problems and anxiety better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10861805 on NIH RePORTER |
What this research studies
This research explores the role of Neuropeptide S (NPS) in regulating sleep and wakefulness, particularly its effects on anxiety and arousal. By using specially engineered mice, the study aims to map the neural circuits involved in NPS signaling and how they influence sleep architecture. The researchers will employ advanced techniques such as viral tracing and fiber photometry to observe the activity of NPS-expressing neurons during different states of sleep and in response to emotional stimuli. This approach could lead to a better understanding of sleep disorders and anxiety-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing sleep disorders or anxiety disorders.
Not a fit: Patients with no sleep or anxiety issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for sleep disorders and anxiety, improving the quality of life for affected patients.
How similar studies have performed: Previous research has shown promise in understanding the role of neuropeptides in sleep regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: De Lecea, Luis — Stanford University
- Study coordinator: De Lecea, Luis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.