Investigating how neurons and astrocytes communicate in the brain
S1P-S1PR1 in bidirectional Neuron-Astrocyte communications
This study is looking at how brain cells called neurons and support cells called astrocytes work together, which is important for a healthy brain, and it hopes to find out how certain proteins help keep neurons alive and growing, which could help us understand brain disorders better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10913477 on NIH RePORTER |
What this research studies
This research explores the interactions between neurons and astrocytes, which are crucial for brain development and function. It focuses on understanding the molecular signals that regulate these interactions and how they influence the formation and plasticity of neural circuits. By examining specific proteins secreted by astrocytes, the study aims to uncover the mechanisms that support neuronal survival and growth. This could lead to insights into brain disorders where these processes are disrupted.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may involve disrupted neuron-astrocyte interactions.
Not a fit: Patients with purely peripheral nervous system disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for brain diseases by enhancing our understanding of neuron-astrocyte communication.
How similar studies have performed: Previous research has shown success in understanding neuron-astrocyte interactions, but this specific approach is novel and aims to uncover new mechanisms.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Singh, Sandeep Kumar — Virginia Commonwealth University
- Study coordinator: Singh, Sandeep Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.