Investigating how mRNA processing affects B cell development and function
mRNA alternative polyadenylation in B cell development
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11077836
This study is looking at how certain changes in the way B cells make their proteins can affect the immune system, especially in people with autoimmune diseases, to help us understand better how to improve treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11077836 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of alternative polyadenylation and splicing of mRNA in the development and activation of B cells, which are crucial for the immune response. By examining how different mRNA isoforms are produced and regulated, the study aims to uncover mechanisms that may lead to misregulated antibody responses associated with autoimmune diseases. The research employs advanced molecular biology techniques to analyze gene expression and mRNA processing in B cells. Patients may benefit from insights gained into how these processes contribute to immune function and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those interested in understanding the genetic factors influencing B cell function.
Not a fit: Patients with non-autoimmune conditions or those not affected by B cell-related disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases by targeting the mechanisms of B cell regulation.
How similar studies have performed: Previous research has shown that alternative mRNA processing plays a significant role in various diseases, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHI, YONGSHENG — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SHI, YONGSHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, autoimmune disorder, autoimmunity disease