Investigating how metabolism affects immune cell behavior at a single-cell level
Official title: Molecular and metabolic influences on the activation of monocytes and macrophages at single-cell resolution
Funded at Northeastern University · NIH-11125832 · Data updated 2026-11-12
This study is looking at how important immune cells called monocytes and macrophages react to different conditions in the body, which could help us understand better how our immune system works and find new ways to treat diseases like atherosclerosis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $393,298 |
| NIH project number | 5R35GM148218-03 |
| Project ID | NIH-11125832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with atherosclerotic cardiovascular disease or related immune system disorders.
✕Less likely to help
Patients with acute infections or those not suffering from metabolic or cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding how monocytes and macrophages, which are crucial immune cells, respond to different metabolic environments. By using advanced techniques to analyze these cells at a single-cell level, the study aims to uncover the diverse ways these cells function and adapt. The researchers will measure proteins and regulatory signals in these immune cells to see how they change in response to various stimuli, including pathogens. This detailed analysis could lead to new insights into immune responses and potential therapeutic targets for diseases like atherosclerosis.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to immune dysfunction and cardiovascular diseases.
How similar studies have gone: Previous research has shown promise in understanding immune cell behavior through single-cell analysis, indicating that this approach could yield valuable insights.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Slavov, Nikolai — Northeastern University
- Study coordinator: Slavov, Nikolai
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.