Investigating how metabolism affects glioblastoma cell behavior
Metabolic Regulation of Glioblastoma Epitranscriptomics
This study is looking at how certain processes in the body affect the growth of glioblastoma, a tough type of brain cancer, to find new ways to help treat it better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10868572 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, one of the most aggressive brain cancers, and aims to understand how metabolic processes influence the behavior of glioblastoma stem cells (GSCs). By examining the role of methyl donor metabolism and epitranscriptomics, the study seeks to identify specific metabolic and molecular targets that could disrupt the growth and survival of these cancer cells. The researchers will use a combination of genetic and pharmacological approaches to explore how altering these metabolic pathways can impact tumor growth and resistance to treatment. Patients may benefit from insights that could lead to more effective therapies for glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with glioblastoma.
Not a fit: Patients with other types of brain tumors or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that specifically target glioblastoma stem cells, potentially improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in glioblastoma, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Agnihotri, Sameer — University of Pittsburgh at Pittsburgh
- Study coordinator: Agnihotri, Sameer
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.