Investigating how mechanical ventilation affects kidney function
Official title: Physiologic and Molecular Mechanisms of Ventilator Induced Kidney Injury
Funded at VA San Diego Healthcare System · NIH-10915843 · Data updated 2026-11-12
This study is looking at how using a breathing machine affects kidney health in critically ill Veterans, with the hope of finding ways to prevent kidney problems that can happen during treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006238-01A2 |
| Project ID | NIH-10915843 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill Veterans who require mechanical ventilation and are at risk for acute kidney injury.
✕Less likely to help
Patients who are not critically ill or do not require mechanical ventilation may not benefit from this research.
What this research studies
This research focuses on understanding the physiological and molecular mechanisms that lead to acute kidney injury (AKI) in patients undergoing mechanical ventilation, particularly in critically ill Veterans. The study aims to identify how mechanical ventilation impacts kidney function, specifically looking at changes in glomerular filtration rate and sodium retention. By using pre-clinical models, the research seeks to uncover the underlying mechanisms that contribute to AKI, which could lead to the development of new treatment strategies to prevent this serious complication. The ultimate goal is to improve patient outcomes by mitigating the risks associated with mechanical ventilation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of acute kidney injury in patients on mechanical ventilation.
How similar studies have gone: While the specific mechanisms of AKI due to mechanical ventilation are still being explored, previous research has shown that understanding physiological changes can lead to improved treatment strategies.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Hepokoski, Mark Lawrence — VA San Diego Healthcare System
- Study coordinator: Hepokoski, Mark Lawrence
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.