Investigating how macrophages contribute to heart disease in people living with HIV
Plaque and blood derived macrophages: a multi-omic assessment of CVD pathogenesis in PLWH
This study is looking at how certain immune cells called macrophages might affect heart disease risk in people living with HIV, and it needs participants to help by providing blood samples to find out more about this connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10914152 on NIH RePORTER |
What this research studies
This research explores the relationship between macrophages and cardiovascular disease (CVD) in individuals living with HIV. It aims to understand how these immune cells behave differently due to inflammatory signals and how this may lead to increased heart disease risk. By analyzing blood samples and macrophage characteristics, the study seeks to identify specific biomarkers and mechanisms that contribute to CVD in this population. Patients may be involved in providing samples and data to help uncover these important connections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be at risk for cardiovascular disease.
Not a fit: Patients who do not have HIV or those without cardiovascular disease risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for cardiovascular disease in people living with HIV.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in cardiovascular disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Funderburg, Nicholas T. — Ohio State University
- Study coordinator: Funderburg, Nicholas T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.