Investigating how lung cells respond to influenza and cause ongoing inflammation
Understanding and targeting fibroblast activation in influenza-triggered lung inflammation and post-viral disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA SANTA CRUZ · NIH-10917321
This study is looking at how the flu can cause long-lasting lung problems and aims to find out how certain lung cells contribute to ongoing inflammation, with the goal of creating better treatments for people who have trouble breathing after getting over the flu.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA CRUZ (nih funded) |
| Locations | 1 site (SANTA CRUZ, UNITED STATES) |
| Trial ID | NIH-10917321 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how influenza virus infections lead to persistent lung inflammation and complications, known as Post-viral Lung Disease (PVLD). It aims to identify the role of specific lung cells, particularly inflammatory fibroblasts, in driving this inflammation and preventing effective lung repair after the virus is cleared. By exploring the cellular and molecular mechanisms involved, the research seeks to develop potential treatments to improve recovery for patients suffering from prolonged respiratory symptoms following influenza infection.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced severe influenza infections and are suffering from ongoing respiratory symptoms or complications.
Not a fit: Patients who have not had influenza infections or those with unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help patients recover more effectively from severe influenza infections and reduce long-term respiratory issues.
How similar studies have performed: While the specific focus on inflammatory fibroblasts in the context of PVLD is relatively novel, similar research has shown promise in understanding lung inflammation and repair mechanisms in other respiratory diseases.
Where this research is happening
SANTA CRUZ, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA CRUZ — SANTA CRUZ, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOYD, DAVID FIELDING — UNIVERSITY OF CALIFORNIA SANTA CRUZ
- Study coordinator: BOYD, DAVID FIELDING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome