Investigating how lung cells respond to Aspergillus fumigatus infections
Aspergillus fumigatus infection and fibrosis
This study is looking at how certain lung cells react when they encounter a mold that can cause serious lung infections, with the goal of finding better ways to help patients recover from these infections and heal their lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10897955 on NIH RePORTER |
What this research studies
This research focuses on understanding how lung fibroblasts, a type of cell involved in tissue repair, respond to infections caused by Aspergillus fumigatus, a mold that can lead to severe pneumonia. The study uses specialized genetic mouse models to observe the activation and deactivation of these cells when exposed to the mold. By examining the inflammatory responses triggered by the infection, the research aims to uncover mechanisms that could enhance the body's ability to clear the infection and repair lung damage. This could provide insights into better treatment strategies for patients suffering from invasive aspergillosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are immunocompromised or critically ill and at risk for invasive aspergillosis.
Not a fit: Patients with healthy immune systems and no risk factors for Aspergillus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with severe lung infections caused by Aspergillus fumigatus.
How similar studies have performed: Previous research has shown promising results in understanding the immune response to fungal infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Askew, David S — University of Cincinnati
- Study coordinator: Askew, David S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.