Investigating how long noncoding RNAs affect T-cell responses in immune reactions.
Long noncoding RNA-mediated regulation of T-cell alloimmunity
This study is looking at how certain molecules in our cells, called long noncoding RNAs, affect the immune response in patients who develop a serious condition called graft-versus-host disease after a stem cell transplant, with the goal of finding better treatments for those patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11013429 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of long noncoding RNAs (lncRNAs) in regulating T-cell responses during acute graft-versus-host disease (GVHD), a serious complication following hematopoietic stem cell transplantation. The project involves training in advanced techniques such as animal models, T-cell functional assays, and bioinformatics to analyze genetic data. By exploring how lncRNAs influence immune responses, the research aims to identify new therapeutic targets for improving treatment outcomes in patients undergoing stem cell transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing allogeneic hematopoietic stem cell transplantation who are at risk for developing acute graft-versus-host disease.
Not a fit: Patients who are not undergoing stem cell transplantation or those who do not have a risk of acute graft-versus-host disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from acute graft-versus-host disease, enhancing their recovery and overall health.
How similar studies have performed: Previous research has shown promising results in understanding the role of lncRNAs in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Peltier, Daniel C. — Indiana University Indianapolis
- Study coordinator: Peltier, Daniel C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.