Investigating how long noncoding RNAs affect T-cell responses in immune reactions.
Official title: Long noncoding RNA-mediated regulation of T-cell alloimmunity
Funded at Indiana University Indianapolis · NIH-11013429 · Data updated 2026-11-12
This study is looking at how certain molecules in our cells, called long noncoding RNAs, affect the immune response in patients who develop a serious condition called graft-versus-host disease after a stem cell transplant, with the goal of finding better treatments for those patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $139,266 |
| NIH project number | 5K08HL157619-04 |
| Project ID | NIH-11013429 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing allogeneic hematopoietic stem cell transplantation who are at risk for developing acute graft-versus-host disease.
✕Less likely to help
Patients who are not undergoing stem cell transplantation or those who do not have a risk of acute graft-versus-host disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of long noncoding RNAs (lncRNAs) in regulating T-cell responses during acute graft-versus-host disease (GVHD), a serious complication following hematopoietic stem cell transplantation. The project involves training in advanced techniques such as animal models, T-cell functional assays, and bioinformatics to analyze genetic data. By exploring how lncRNAs influence immune responses, the research aims to identify new therapeutic targets for improving treatment outcomes in patients undergoing stem cell transplants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from acute graft-versus-host disease, enhancing their recovery and overall health.
How similar studies have gone: Previous research has shown promising results in understanding the role of lncRNAs in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Peltier, Daniel C. — Indiana University Indianapolis
- Study coordinator: Peltier, Daniel C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.