Investigating how Lipin-1 helps macrophages resolve inflammation in cardiovascular disease
Official title: Lipin-1 transcriptional coregulatory activity promotes macrophage pro-resolving response
Funded at Louisiana State Univ Hsc Shreveport · NIH-10901835 · Data updated 2026-11-12
This study is looking at how a protein called Lipin-1 helps immune cells called macrophages reduce inflammation in heart disease, with the hope of finding new ways to improve heart health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $550,760 |
| NIH project number | 5R01HL163106-02 |
| Project ID | NIH-10901835 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with atherosclerotic cardiovascular disease or those at high risk for developing it.
✕Less likely to help
Patients who do not have cardiovascular disease or related inflammatory conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of Lipin-1 in macrophages, which are immune cells that help resolve inflammation in atherosclerotic cardiovascular disease (ACVD). The study aims to explore how Lipin-1 influences the metabolism of fatty acids during the resolution of inflammation, potentially leading to better outcomes for patients with ACVD. By examining the pathways involved in lipid metabolism and inflammation resolution, the research seeks to identify new therapeutic targets that could improve heart health. Patients may benefit from insights gained about how to enhance the body's natural ability to resolve inflammation without increasing the risk of infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the resolution of inflammation in patients with cardiovascular disease, potentially reducing their risk of heart attacks and strokes.
How similar studies have gone: Previous research has shown promising results in targeting inflammation resolution in cardiovascular disease, suggesting that this approach could be effective.
Where this research is happening
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Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Woolard, Matthew Dale — Louisiana State Univ Hsc Shreveport
- Study coordinator: Woolard, Matthew Dale
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.