Investigating how lipids affect kidney damage in Alport syndrome
Official title: Glomerular endothelial damage: a new role of the lipids in Alport syndrome
Funded at Children's Hospital of Los Angeles · NIH-11001584 · Data updated 2026-11-12
This study is looking at how fats in the body affect kidney problems in people with Alport syndrome, and it hopes to find new ways to help manage or treat the condition by using special cells from amniotic fluid.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 16, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $335,265 |
| NIH project number | 5R01DK135806-02 |
| Project ID | NIH-11001584 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alport syndrome or related hereditary nephritis.
✕Less likely to help
Patients with kidney diseases unrelated to Alport syndrome may not benefit from this research.
What this research studies
This research focuses on understanding the role of lipids in the progression of Alport syndrome, a genetic disorder that leads to kidney disease. By studying the changes in lipid metabolism in glomerular endothelial cells, researchers aim to uncover the molecular mechanisms that contribute to kidney damage. The approach involves analyzing genetic and lipidomic data from a mouse model of Alport syndrome, as well as exploring potential therapeutic benefits from extracellular vesicles derived from amniotic fluid stem cells. This research could provide new insights into how to better manage or treat this condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent kidney damage in patients with Alport syndrome.
How similar studies have gone: While the specific focus on lipid metabolism in Alport syndrome is novel, similar approaches in other kidney diseases have shown promising results.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Sedrakyan, Sargis — Children's Hospital of Los Angeles
- Study coordinator: Sedrakyan, Sargis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.