Investigating how leprosy affects nerve cells through lipid droplets
The Role of Schwann Cell Lipid Droplets In Neuropathology of Leprosy
This study is looking at how the bacteria that cause leprosy affect nerve cells in the body, specifically how they create fat droplets that can harm nerves and lead to disabilities, with the hope of finding new ways to help treat leprosy and protect nerve function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-10651645 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between the leprosy-causing bacteria, Mycobacterium leprae, and Schwann cells, which are crucial for nerve function. The study aims to explore how these bacteria induce the formation of lipid droplets in Schwann cells, leading to nerve damage and physical disabilities associated with leprosy. By examining the molecular mechanisms involved, the research seeks to uncover potential targets for new treatments that could mitigate the effects of leprosy on the nervous system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with leprosy, particularly those experiencing neurological symptoms.
Not a fit: Patients who do not have leprosy or those with advanced, irreversible nerve damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for leprosy that prevent nerve damage and associated disabilities.
How similar studies have performed: While the specific interactions of M. leprae with Schwann cells are not extensively studied, similar research on bacterial infections and nerve damage has shown promising results.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Belisle, John T — Colorado State University
- Study coordinator: Belisle, John T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.