Investigating how Leiomodin1 affects blood vessel growth in low oxygen conditions
Official title: The Role of Leiomodin1 in Hypoxic Neovessel Maturation
Funded at University of Alabama at Birmingham · NIH-11133784 · Data updated 2026-11-12
This study is looking at how a protein called Leiomodin1 (LMOD1) helps create new blood vessels in people with peripheral artery disease (PAD), which can make it hard for blood to flow to the legs, especially when there's not enough oxygen, to find better ways to help improve blood flow for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | May 15, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $687,517 |
| NIH project number | 1R01HL167861-01A1 |
| Project ID | NIH-11133784 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with peripheral artery disease who experience reduced blood flow in their limbs.
✕Less likely to help
Patients who do not have peripheral artery disease or related cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of Leiomodin1 (LMOD1) in the development of new blood vessels in patients with peripheral artery disease (PAD), a condition that affects blood flow in the limbs. The study aims to explore the molecular mechanisms by which LMOD1 influences the maturation of these blood vessels, particularly in the context of low oxygen levels. By using animal models, the researchers will assess how changes in LMOD1 expression impact blood vessel formation and stability, which could lead to new therapeutic strategies for improving blood flow in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance blood vessel growth and improve blood flow for patients suffering from peripheral artery disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of molecular factors in blood vessel formation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Nanda, Vivek — University of Alabama at Birmingham
- Study coordinator: Nanda, Vivek
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.