Investigating how Latexin affects lung function in inflammatory lung injury
Targeting Latexin Signaling for Endothelial Barrier Dysfunction in Inflammatory Lung Injury
This study is looking at a protein called Latexin to see how it affects lung problems in people with Acute Respiratory Distress Syndrome (ARDS), with the hope of finding new ways to help improve breathing for those who are struggling.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10911977 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Latexin in endothelial dysfunction associated with Acute Respiratory Distress Syndrome (ARDS). By examining how Latexin levels change in response to inflammation, the study aims to uncover the mechanisms that lead to lung injury and respiratory failure. The researchers will utilize various laboratory techniques, including mass spectrometry and cellular assays, to explore how Latexin interacts with other proteins and affects lung endothelial cells. The ultimate goal is to identify potential therapeutic targets that could improve lung function in patients suffering from ARDS.
Who could benefit from this research
Good fit: Ideal candidates for this research include critically ill patients diagnosed with Acute Respiratory Distress Syndrome.
Not a fit: Patients with chronic respiratory conditions unrelated to ARDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung function and reduce mortality in patients with ARDS.
How similar studies have performed: Previous research has shown promising results in targeting endothelial dysfunction in lung injuries, suggesting that this approach could be effective.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Sun, Jianxin — Thomas Jefferson University
- Study coordinator: Sun, Jianxin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.