Investigating how KLF15 affects kidney cell metabolism
Official title: Role of KLF15 in proximal tubule metabolism
Funded at Northport VA Medical Center · NIH-10950353 · Data updated 2026-11-12
This study is looking at how a specific protein in kidney cells can help us understand what happens when kidneys get hurt and how that might lead to long-term problems, with the hope of finding new ways to keep your kidneys healthy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northport VA Medical Center NIH-funded |
| Lab location | 1 site (Northport, United States) |
| Project start | January 1, 2018 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX003698-07 |
| Project ID | NIH-10950353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced acute kidney injury or are at risk for chronic kidney disease, particularly U.S. Veterans.
✕Less likely to help
Patients with stable chronic kidney disease who have not experienced acute kidney injury may not benefit from this research.
What this research studies
This research focuses on understanding the role of KLF15, a transcription factor, in the metabolism of proximal tubule cells in the kidneys. It examines how acute kidney injury (AKI) can lead to chronic kidney disease (CKD) and the cellular changes that occur during this process. The study looks at how damaged kidney cells respond to injury and the potential for metabolic reprogramming to prevent further damage. By exploring these mechanisms, the research aims to identify new therapeutic targets to improve kidney health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression from acute kidney injury to chronic kidney disease, improving outcomes for patients.
How similar studies have gone: Previous research has shown that targeting metabolic pathways can mitigate kidney injury in animal models, suggesting potential for success in human applications.
Where this research is happening
-
Northport VA Medical Center
Northport, United States Active
Researchers
- Principal investigator: Mallipattu, Sandeep K — Northport VA Medical Center
- Study coordinator: Mallipattu, Sandeep K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.